IMPORTANT EFFECTS OF BETA BLOCKERS
• Myocardial O demand is decreased due to blockade of beta1 receptors in the heart useful in classical angina
• Coronary vasoconstriction can occur due to blockade of beta 2 receptors so contraindicated in variant angina
• decrease in blood pressure due to B1 blocking action
• Bronchoconstriction may occur due to blockage of b2 receptors contraindicated in asthmatics
• Dyslipidemia characterized by increase in LDL and decrease in HDL may be seen due to B2 blockade
• Decreased chances of reversal of hypoglycemia in patients on insulin and other hypoglycemic agents by b2 blocking action
• Decreased production of aqueous humour useful in glaucoma by beta 2 blocking action
• Impaired exercise capacity due to blockade of beta 2 receptors in blood vessels of skeletal muscles.
• Abolishes sympathetic tremors (beta 2 blockade).
CARDIOSELECTIVE B BLOCKERS
• Nebivolol most cardioselective
• Betaxolol
• Bisoprolol
• Acebutolol
• Esmolol
• Atenolol
• Metoprolol
• celiprolol
THEY ARE INDICATED IN DIABETES MELLITUS , BRONCHIAL ASTHMA AND PERIPHERAL VASCULAR DISEASE